|
|
5alpha-Androstane-3beta,17beta-diol + NADP+ <=> 5alpha-dihydrotestosterone + NADPH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
–
–
–
|
M
|
| |
BRENDA:
BR29254
KEGG:
R04344
MetaCyc:
1.1.1.210-RXN
SABIO-RK:
7050;
8080
|
|
|
|
5alpha-androstane-3alpha,17beta-diol + NAD+ <=> 5alpha-dihydrotestosterone + NADH + H+
|
1.1.1.105
all-trans-retinol dehydrogenase (NAD+)
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
–
–
–
–
–
–
–
–
|
|
| |
BRENDA:
BR29317
KEGG:
R04330
MetaCyc:
1.1.1.53-RXN;
RXN-12264_WOP
SABIO-RK:
7910
|
|
|
|
5alpha-androstane-3alpha,17beta-diol + NADP+ <=> 5alpha-dihydrotestosterone + NADPH + H+
|
1.1.1.105
all-trans-retinol dehydrogenase (NAD+)
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
1.3.1.20
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
|
–
–
–
–
–
–
–
–
–
–
|
K
|
| |
BRENDA:
BS187692;
BS257212-a
KEGG:
R08963
MetaCyc:
RXN-12264
SABIO-RK:
7911
|
|
|
|
5alpha-dihydrotestosterone + NADP+ <=> testosterone + H+ + NADPH
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
–
|
MK
|
| |
BRENDA:
BS258429
KEGG:
R02497
MetaCyc:
RXN66-343
SABIO-RK:
11551
|
|
|
|
5alpha-dihydrotestosterone + NADP+ <=> 5alpha-androstane-3,17-dione + NADPH
|
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
1.3.1.20
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
|
–
–
–
–
–
–
–
|
|
| |
BRENDA:
BS188305;
BS384190
SABIO-RK:
11795
|
|
|
|
5alpha-dihydrotestosterone + NAD+ <=> androstanedione + NADH
|
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
–
|
|
| |
BRENDA:
BS188496;
BS188506
SABIO-RK:
11209
|
|
|
|
5alpha-dihydrotestosterone + NADH <=> androstanediol + NAD+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.150
21-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
–
–
|
|
| |
BRENDA:
BS397003
SABIO-RK:
13670
|
|
|
|
androstanediol + NADP+ <=> 5alpha-dihydrotestosterone + NADPH + H+
|
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
–
|
|
| |
BRENDA:
BS422771
SABIO-RK:
11548
|
|
|
|
5alpha-dihydrotestosterone + 2 reduced_ferredoxin_[iron-sulfur]_cluster + 2 H+ + O2 <=> 9alpha,17beta-dihydroxy-5alpha-androstane-3-one + 2 oxidized_ferredoxin + H2O
|
1.14.15.30
3-ketosteroid 9alpha-monooxygenase
|
–
|
|
| |
BRENDA:
BS418330
|
|
|
|
5alpha-dihydrotestosterone + 2,6-dichlorophenolindophenol <=> 5alpha-androst-1-ene-17beta-ol-3-one + reduced_2,6-dichlorophenolindophenol
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
| |
BRENDA:
BS440945
|
|
|
|
5alpha-dihydrotestosterone + 2,6-dichlorophenolindophenol <=> (5alpha,17beta)-17-hydroxyandrost-1-en-3-one + reduced_2,6-dichlorophenolindophenol
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
| |
BRENDA:
BS396032
|
|
|
|
5alpha-dihydrotestosterone + UDP-glucuronate <=> dihydrotestosterone_D-glucuronate + UDP
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
| |
BRENDA:
BS420603
|
|
|
|
5alpha-dihydrotestosterone + UDP-glucuronate <=> UDP + 17beta-hydroxy-5alpha-androstan-3-one_17O-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
| |
BRENDA:
BS322191
|
|
|
|
5alpha-dihydrotestosterone + UDP-glucuronate <=> UDP + dihydrotestosterone_O-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
| |
BRENDA:
BS322236
|
|
|
|
UDP-glucuronate + 5alpha-dihydrotestosterone <=> UDP + dihydrotestosterone_17-O-beta-D-glucuronoside
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
| |
BRENDA:
BS399073
|
|
|
|
5alpha-dihydrotestosterone + NADH + H+ <=> testosterone + NADH + H+
|
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
|
–
|
|
| |
BRENDA:
BS438918
|
|
|
|
5alpha-dihydrotestosterone + NADH <=> 5alpha-androstane-3,17-dione + NAD+
|
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
|
|
| |
BRENDA:
BS188486
|
|
|
|
5alpha-dihydrotestosterone + NADH + H+ <=> (5alpha,17beta)-androstane-3,17-diol + NAD+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
|
|
| |
BRENDA:
BS422686-a
|
|
|
|
5alpha-Androstan-3alpha-ol-17-one + NAD+ <=> 5alpha-dihydrotestosterone + NADH + H+
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS451075
|
|
|
|
5alpha-dihydrotestosterone + NADH <=> 5alpha-Androstane-3beta,17beta-diol + NAD+
|
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
|
| |
BRENDA:
BS188059
|
|
|
|
5alpha-dihydrotestosterone + NADH + H+ <=> androstane-3beta,17beta-diol + NAD+
|
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
|
|
| |
BRENDA:
BS384612-a
|
|
|
|
5alpha-dihydrotestosterone + NADH + H+ <=> 3alpha,17beta-dihydroxy-5alpha-androstan + NAD+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
|
–
|
|
| |
BRENDA:
BS370092-a
|
|
|
|
5alpha-dihydrotestosterone + NADH <=> androstanedione + NAD+
|
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS187721-a
|
|
|
|
5alpha-dihydrotestosterone + NAD+ <=> 5alpha-Androstan-3,17-dione + NADH
|
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
|
|
| |
BRENDA:
BS257214
|
|
|
|
5alpha-androstane-3alpha,17beta-diol + NADH <=> 5alpha-dihydrotestosterone + NAD+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
|
| |
BRENDA:
BS257205-a
|
|
|
|
5alpha-dihydrotestosterone + NAD+ <=> 5beta-androstane-3,17-dione + NADH
|
1.1.1.1
alcohol dehydrogenase
|
–
|
|
| |
BRENDA:
BS186903
|
|
|
|
5alpha-dihydrotestosterone + NAD+ <=> 5alpha-17-oxo-dihydrotestosterone + NADH
|
1.1.1.112
indanol dehydrogenase
|
–
|
|
| |
BRENDA:
BS187031-a
|
|
|
|
5alpha-dihydrotestosterone + NADH + H+ <=> 3beta,17beta-Dihydroxy-5alpha-androstan + NAD+
|
1.1.1.1
alcohol dehydrogenase
|
–
|
|
| |
BRENDA:
BS186913
|
|
|
|
5alpha-androstanediol + NAD+ <=> 5alpha-dihydrotestosterone + NADH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS257035
|
|
|
|
5alpha-androstane-3,17-diol + NAD+ <=> 5alpha-dihydrotestosterone + NADH
|
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
|
–
|
|
| |
BRENDA:
BS386159
|
|
|
|
3alpha,17beta-androstene-3,17-diol + NAD+ <=> 5alpha-dihydrotestosterone + NADH + H+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
|
| |
BRENDA:
BS403789-a
|
|
|
|
testosterone + NADPH <=> 5alpha-androstane-3alpha,17beta-diol + androstane-3beta,17beta-diol + 5alpha-dihydrotestosterone
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
|
| |
BRENDA:
BS258534
|
|
|
|
5alpha-Androstan-3alpha-ol-17-one + Alpha-NAD+ <=> 5alpha-dihydrotestosterone + alpha-NADPH + H+
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS451072
|
|
|
|
5alpha-dihydrotestosterone + alpha-NADPH + H+ <=> 5alpha-Androstan-3alpha-ol-17-one + alpha-NADP+
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS451074
|
|
|
|
5alpha-dihydrotestosterone + NADPH + H+ <=> 5alpha-Androstane-3beta,17beta-diol + 5alpha-androstane-3,17-dione + NADP+
|
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
|
|
| |
BRENDA:
BS425809
|
|
|
|
5alpha-dihydrotestosterone + NADPH <=> 5alpha-androstane-3,17-dione + NADP+
|
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
|
|
| |
BRENDA:
BS188487
|
|
|
|
5alpha-dihydrotestosterone + NADPH + H+ <=> (5alpha,17beta)-androstane-3,17-diol + NADP+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
|
|
| |
BRENDA:
BS422686
|
|
|
|
2 5alpha-dihydrotestosterone + 2 NADPH + 2 H+ <=> 5alpha-Androstane-3beta,17beta-diol + 5alpha-androstane-3alpha,17beta-diol + 2 NADP+
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
|
|
| |
BRENDA:
BS370770
|
|
|
|
5alpha-dihydrotestosterone + NADH <=> 5alpha-Androstane-3beta,17beta-diol + NADP+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS188307-a
|
|
|
|
5alpha-dihydrotestosterone + NADPH + H+ <=> androstane-3beta,17beta-diol + NADP+
|
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
|
|
| |
BRENDA:
BS384612
|
|
|
|
5alpha-dihydrotestosterone + NADPH <=> 3alpha,17beta-dihydroxy-5alpha-androstan + NADP+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
|
–
|
|
| |
BRENDA:
BS230608
|
|
|
|
5alpha-dihydrotestosterone + NADPH <=> androstanedione + NADP+
|
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS187721
|
|
|
|
5alpha-dihydrotestosterone + NADPH <=> 5alpha-androstane-3alpha,17alpha-diol + NADP+
|
1.1.1.148
estradiol 17alpha-dehydrogenase
|
–
|
|
| |
BRENDA:
BS383962
|
|
|
|
5alpha-dihydrotestosterone + NADP+ <=> 5alpha-17-oxo-dihydrotestosterone + NADH
|
1.1.1.112
indanol dehydrogenase
|
–
|
|
| |
BRENDA:
BS187031
|
|
|
|
Boc-Gly-Lys-Arg-4-methylcoumarin_7-amide + NADPH <=> 5alpha-dihydrotestosterone + NADP+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS388537
|
|
|
|
5alpha-dihydrotestosterone + NADP+ <=> 5alpha-Androstan-3,17-dione + NADPH
|
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
|
|
| |
BRENDA:
BS188430
|
|
|
|
5alpha-androstane-3alpha,17beta-diol + NADPH <=> 5alpha-dihydrotestosterone + NADP+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
–
–
|
|
| |
BRENDA:
BS257205
|
|
|
|
5alpha-dihydrotestosterone + NADP+ <=> 5alpha-17-oxo-dihydrotestosterone + NADPH
|
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
|
|
| |
BRENDA:
BS188518
|
|
|
|
5-androstene-3,17-dione + NADPH <=> 5alpha-dihydrotestosterone + NADP+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS386154
|
|
|
|
3alpha,17beta-androstene-3,17-diol + NADP+ <=> 5alpha-dihydrotestosterone + NADPH + H+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
|
| |
BRENDA:
BS403789
|
|
|
|
testosterone + reduced_acceptor <=> 5alpha-dihydrotestosterone + acceptor
|
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
|
|
| |
BRENDA:
BS258869
|
|
